Application

PRODUCT NAME	:	NITROTOLUENE (O-)
CAS number	:	88-72-2
UN number	:	1664
Formula	:	NO2C6H4CH3
Odour	:
Solubility in water	:	INSOLUBLE
Density	:	1.163 at 20 ^oC
Boiling point	:	220 ^oC
Melting point	:	-9 ^oC
Viscosity	:	2.37 cp at 20 ^oC
Flashpoint	:	106 ^oC
Explosive limits	:
Vapour pressure	:	.1 mbar at 20 ^oC
Skin absorption/irritation	:	YES
TLV Country NL Year 1989	:	2 S ppm 11 S mg/m3
Pollution category 1994	:	B

Dosage

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MSDS

Product Name	Nitro Toluene (O-)
Part Number	RXSOL-19-1397-025

Company Details:

RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA

Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA

Phone	+91 22 20871200 - 1400
Fax	+91 22 27612100 :::AOH :0091 9821214367
Email	mail@rxmarine.com
Website	www.rxmraine.comA

Chemical Name	CAS	EC number	Weight	Formula
2-Nitrotoluene	88-72-2	201-853-3	<= 100 %	C₇H₇NO₂

Signal Word	Danger
Hazard Statements	H302 Harmful if swallowed. H340 May cause genetic defects. H350 May cause cancer. H361f Suspected of damaging fertility. H411 Toxic to aquatic life with long lasting effects.
Precautionary statements	P202 Do not handle until all safety precautions have been read and understood. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Classification of the substance or mixture	Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
Supplemental Hazard Statements	None.
Other hazards	This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

General advice	Show this material safety data sheet to the doctor in attendance.
If inhaled	After inhalation: fresh air. Call in physician.
Eye Contact	After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
Swallowed	After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Skin Contact	In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
Inhalation	Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary.
Ingestion	Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delaye	The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
Indication of any immediate medical attention and special treatment needed	No data available

Flammability	Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Suitable extinguishing media	Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media	For this substance/mixture no limitations of extinguishing agents are given.
Special hazards arising from the substance or mixture	Carbon oxides Nitrogen oxides (NOx) Combustible. Fire may cause evolution of: nitrogen oxides Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Further information	Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Hazardous combustion products	Fire may cause the evolution of Sulphur oxides, nitrogen oxides.
Advice for firefighters	Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Protective Equipment	Use personal protective equipment.
Specific Hazards Arising from the Chemical	Oxides of phosphorus Sodium oxides Not combustible. Fire may cause evolution of: Oxides of phosphorus Ambient fire may liberate hazardous vapours.

Personal precautions, protective equipment and emergency procedures	Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Spillage	Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal.
Enviromental Precaution	Do not let product enter drains.
Methods and materials for containment and cleaning	Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area.

Advice on protection against fire and explosion	Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Incompatible materials	Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills.
Hygiene measures	Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2.
Precautions for safe handling	Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols..
Storage conditions	Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. Recommended storage temperature see product label.
Storage class	Storage class (TRGS 510): 6.1A: Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Specific end use(s)	Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
Advice on general occupational hygiene	Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance.
Requirements for storage	Keep in cool and store under shade.

Exposure controls	Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Control parameters	Ingredients with workplace control parameters Contains no substances with occupational exposure limit values.
Engineering Control	Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Eye/face protection	Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Body Protection	Protective clothing.
Skin protection	This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject® (KCL 898) This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,4 mm Break through time: 30 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Respiratory protection	Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Other Protection Measure	Handle in accordance with good industrial hygiene and safety practice.
Control of environmental exposure	Do not let product enter drains.

Physical state	Oily
Colour	Yellow
Odour	Of solvents
Odor Threshold	No data available
pH	No data available
Melting Point	6 - 8
Boiling Point	221 - 222 °C at 1.013 hPa
Flash Point	95 °C - closed cup
Evaporation Rate	Not Applicable
Flammability (solid, gas)	No data available
Explosive limits	No Data Available
Upper/lower flammability or explosive limits	8,8 %(V) / 1,47 %(V)
Autoignition temperature	No data available
Decomposition temperature	No data available
Vapour pressure	0,1 hPa at 20 °C
Density	1,16 g/cm3 at 20 °C
Relative Density	No data available
Relative vapor density	4,73
Freezing point	No data available
Viscosity dynamic	No data available
Partition coefficient	log Pow: 2,30 -
Explosive properties	No data available
Solubility	0,65 g/l at 20 °C -
Ignition temperature	No information available.
Particle characteristics	No data available

Reactivity	Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Stability	The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions	Exothermic reaction with: Strong oxidizing agents Risk of explosion with: Sulfur trioxide sulfuric acid Reducing agents increased reactivity with: strong alkalis Amines
Conditions to avoid	Strong heating.
Incompatible materials	No data available
Hazardous decomposition products	In the event of fire: see section 5

Acute toxicity	LD50 Oral - Rat - 891 mg/kg Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis. Remarks: (RTECS) Oral: absorption Symptoms: Dizziness, Nausea, Vomiting Inhalation: absorption Dermal: absorption
Skin corrosion/irritation	Skin - Rabbit Result: No skin irritation - 24 h (OECD Test Guideline 404)
Serious eye damage/eye irritation	Eyes - Rabbit Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization	Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429)
Toxic Effects on Human	May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer).
Carcinogenicity	Carcinogenicity - (ECHA) Presumed to have carcinogenic potential for humans
Germ cell mutagenicity	May cause genetic defects. Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 479 Result: positive Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473 Result: negative Test Type: Mutagenicity (mammal cell test): micronucleus. Test system: Chinese hamster lung cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 487 Result: positive Test Type: Unscheduled DNA synthesis test (UDS) in testicular cells Species: Rat Cell type: Liver cells Application Route: Oral Method: OECD Test Guideline 486 Result: positive
Reproductive toxicity	Suspected of damaging fertility.
Specific target organ toxicity - single exposure	May cause respiratory irritation.
Special Remarks on other Toxi Effects on Humans	Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism.
Endocrine disrupting properties	: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Systemic effects: Methaemoglobinaemia with headache, cardiac arrhythmia, drop in blood pressure, dyspnoea, and spasms, key symptom: cyanosis (blue colouration of the blood). Effect potentiated by: ethanol flush of face, neck and arms muscular weakness cardiovascular disorders confusion Absorption may result in damage of the following: Liver Kidney spleen The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pressure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).

Bioaccumulative potential	Bioaccumulation Lepomis macrochirus - 14 d at 16 °C - 0,957 mg/l(1,2-Dichloroethane) Bioconcentration factor (BCF): 2
Persistence and degradability	Biodegradability aerobic - Exposure time 20 d Result: > 90 % - Inherently biodegradable. Remarks: (ECHA)
Toxicity to fish	Flow-through test LC50 - Pimephales promelas (fathead minnow) - 136 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia and other aquatic invertebrates	Static test EC50 - Daphnia magna (Water flea) - 160 mg/l - 48 h Remarks: (in soft water) (IUCLID)
Toxicity to algae	Static test EC50 - Desmodesmus subspicatus (green algae) - 166 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria	Static test EC50 - activated sludge - 35.500 mg/l - 3 h (OECD Test Guideline 209)
Mobility in soil	No Information available
Results of PBT and vPvB assessment	This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Endocrine disrupting properties	The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Other adverse effects	Discharge into the environment must be avoided.

Disposal methods	The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging	Dispose of as unused product.
Waste treatment Method	See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

UN number	ADR/RID:1664 IMDG:1664 IATA:1664
UN proper shipping name	ADR/RID:Nitrotoluenes, liquid IMDG:Nitrotoluenes, liquid IATA:Nitrotoluenes, liquid
Transport hazard class(es)	ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group	ADR/RID: II IMDG: II IATA: II
Environmental hazards	ADR/RID: YES IMDG: YES IATA: NO
Further information	No data available

Inventory status	Components are on the following inventories: Polymaleic acid: - US TSCA, Canadian DSL, EU EINECS, Australian AICS, Korean, Philippine PICCS and Chinese Xi irritant R 36/38 Irritant to eyes & skin R 41 Risk of serious damage to eyes S24/25 Avoid contact with skin and eyes S26/28 In case of contact eyes & skin, rinse with plenty water and seek medical advice Section 312/313: Not listed. Not listed under California proposition 65.
Safety, health and environmental regulations/legislation specific for the substance or mixture	This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.
Authorisations and/or restrictions on use	REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII) : 2-nitrotoluene
National legislation	Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. E2 ENVIRONMENTAL HAZARDS
Other regulations	Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work.
Chemical Safety Assessment	For this product a chemical safety assessment was not carried out

Other Information

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.

DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.