Application

PRODUCT NAME	:	DIMETHYLACETAMIDE (N,N-)
CAS number	:	127- 19-5
UN number	:
Formula	:	CH3CON(CH3)2
Odour	:
Solubility in water	:	COMPLETE
Density	:	0.943 at 20 ^oC
Boiling point	:	166 ^oC
Melting point	:	-20 ^oC
Viscosity	:
Flashpoint	:	66 ^oC
Explosive limits	:	2 – 11.5 Vol%
Vapour pressure	:	3.3 mbar at 20 ^oC
Skin absorption/irritation	:	YES
TLV Country NL Year 1995	:	10 S ppm 35 S mg/m3
Pollution category 1994	:	D

Dosage

Technical Specification

DIMETHYLACETAMIDE (DMAC)
Test	Results
Purity	99.7%
Appearance	Clear liquid
Water	0.1% max.
Colour (APHA)	10 max.
Distillation Range	160-165 cen.
refractive Index (25 cen)	1.4358-1.4360
Acid (acetic acid)	0.1% max.
Packing	200 Kgs HDPE Drums

MSDS

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Product Name	DI METHYL ACETAMIDE N,N
Part Number	RXSOL-19-1138-025

Company Details:

RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA

Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA

Phone	+91 22 20871200 - 1400
Fax	+91 22 27612100 :::AOH :0091 9821214367
Email	mail @ rxmarine.com
Website	www.rxmraine.com

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Chemical Name	CAS	EC number	Weight	Formula
N,N-Dimethylacetamide	127-19-5	204-826-4	<= 100 %	C₄H₉NO

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Signal Word	Danger
Hazard Statements	H312 + H332 Harmful in contact with skin or if inhaled. H319 Causes serious eye irritation. H360D May damage the unborn child.
P280 Wear protective gloves.P305 + P351 + P338	Wear eye protection/ face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Precautionary statements response	P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 + P312 IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/ doctor if you feel unwell. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Classification of the substance or mixture	Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
Supplemental Hazard Statements	None
Other hazards	This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Rapidly absorbed through skin.

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General advice	Show this material safety data sheet to the doctor in attendance.
If inhaled	After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
Eye Contact	After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
Swallowed	After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Skin Contact	In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
Inhalation	Remove patient to fresh air, keep warm and at rest and get medical assistance in necessary.
Ingestion	Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delaye	The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
Indication of any immediate medical attention and special treatment needed	No data available

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Flammability	May be combustible at high temperature.
Flash Point	Higher than 93.3°C (200°F).
Suitable extinguishing media	Carbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media	For this substance/mixture no limitations of extinguishing agents are given.
Special hazards arising from the substance or mixture	Carbon oxides Nitrogen oxides (NOx) Combustible. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Further information	Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Hazardous combustion products	Fire may cause the evolution of Sulphur oxides, nitrogen oxides.
Advice for firefighters	Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Protective Equipment	Use personal protective equipment.
Specific Hazards Arising from the Chemical	Has a fire-promoting effect due to the release of oxygen. Ambient fire may liberate hazardous vapours.

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Personal precautions, protective equipment and emergency procedures	Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
Spillage	Oxidizing material. Stop leak if without risk. Avoid contact with a combustible material (wood, paper, oil, clothing...). Keep substance damp using water spray. Do not touch spilled material. Prevent entry into sewers, basements or confined areas dike if needed. Eliminate all ignition sources. Call for assistance on disposal.
Personal Protection	Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8.
Enviromental Precaution	Do not let product enter drains.
Methods and materials for containment and cleaning	Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area.

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Advice on safe handling	Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion	Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Incompatible materials	Keep away from alkalis, strong oxidizing agents and metals. Provide containment walls of adequate capacity to hold any accidental spills.
Hygiene measures	Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2.
Precautions for safe handling	For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities	Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Storage conditions	Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons. Store under inert gas. Hygroscopic.
Storage class	Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Specific end use(s)	Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
Handling	Keep away from heat. Keep away from sources of ignition. Keep away from combustible material.. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as reducing agents, combustible materials, organic materials, metals
Advice on general occupational hygiene	Advice on safe handling Observe label precautions. Change contaminated clothing. Wash hands after working with substance.
Requirements for storage	Keep in cool and store under shade.

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Application Area	Routes of exposure	Health effect	Value
Workers	Skin contact	Long-term systemic effects	13,6mg/kg BW/d
Workers	Inhalation	Long-term systemic effects	36 mg/m3

Predicted No Effect Concentration (PNEC)

Compartment	Value
Sea water	0,0966 mg/l
Fresh water	0,5 mg/l
Sewage treatment plant	485 mg/l
Aquatic intermittent release	5 mg/l

Exposure controls	No specific additional engineering controls are required. Provide good natural or artificial ventilation.
Engineering Control	Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Eye/face protection	Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Body Protection	Protective clothing
Skin protection	This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject® (KCL 898) This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,4 mm Break through time: 30 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Respiratory protection	Recommended Filter type: Filter A-(P3) The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Other Protection Measure	Handle in accordance with good industrial hygiene and safety practice.
Control of environmental exposure	Do not let product enter drains.
Thermal hazards	No data available

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Physical state	Liquid, clear
Colour	Colorless
Odour	Ammonia odor
Odor Threshold	Not Applicable
pH	ca.4 at 200 g/l at 20 °C
Melting Point	-20 °C - lit.
Boiling Point	164,5 - 166 °C - lit.
Flash Point	64 °C - closed cup
Evaporation Rate	Not Applicable
Flammability (solid, gas)	No data available
Explosive limits	No Data Available
Upper/lower flammability or explosive limits	11,5 %(V) / 1,8 %(V)
Autoignition temperature	345 °C at 999 - 1.011 hPa
Decomposition temperature	No data available
Viscosity, dynamic	0,92 mPa.s at 25 °C
Vapour pressure	2 hPa at 21,7 °C
Density	0,937 g/mL at 25 °C - lit.
Vapour Density	3,01 - (Air = 1.0)
Freezing point	No data available
Specific Gravity	No data available
Partition coefficient	log Pow: -0,77
Explosive properties	No data available
Solubility	1.000 g/l at 20 °C
Ignition temperature	No information available.
Particle characteristics	No data available

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Reactivity	Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Stability	The product is chemically stable under standard ambient conditions (room temperature) . hygroscopic
Possibility of hazardous reactions	Violent reactions possible with: Oxidizing agents Bases Reducing agents Amines
Conditions to avoid	Strong heating.
Incompatible materials	No data available
Hazardous Polymerization	In the event of fire: see section 5

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Acute toxicity	LD50 Oral - Rat - 4.300 mg/kg Remarks: (RTECS) Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract. LC50 Inhalation - Rat - female - 1 h - 8,8 mg/l - vapor (OECD Test Guideline 403) Remarks: (ECHA) Acute toxicity estimate Dermal - 1.100,1 mg/kg (Expert judgment) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation	Skin - Rabbit Result: No skin irritation (OECD Test Guideline 404)
Serious eye damage/eye irritation	Eyes - Rabbit Result: Irritating to eyes. (OECD Test Guideline 405)
Respiratory or skin sensitization	Local lymph node assay (LLNA) - Guinea pig Result: negative (OECD Test Guideline 429)
Toxicity to Animal	WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE Acute oral toxicity (LD50): 689 mg/kg [Rat].
Toxic Effects on Human	May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer).
Carcinogenicity	Carcinogenicity - No carcinogenic properties suspected. (IUCLID)
Germ cell mutagenicity	Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Human lymphocytes Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473 Result: negative Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster lung cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476 Result: negative
Reproductive toxicity	May damage the unborn child.
Specific target organ toxicity - single exposure	No data available
Special Remarks on other Toxi Effects on Humans	Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism.
Endocrine disrupting properties	The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Repeated dose toxicity - Rat - male and female - Oral - 2 yr - NOAEL (No observed adverse effect level) - 100 - 300 mg/kg - LOAEL (Lowest observed adverse effect level) - 300 - 1.000 mg/kg RTECS: AB7700000 impaired judgment, emotional instability, toxic psychosis, nystagmus, dysarthria, Ataxia. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. After absorption of toxic quantities: Nausea Vomiting inebriation muscle twitching hallucinations Diarrhea lack of appetite narcosis Coma Damage to: Liver Kidney Central nervous system Other dangerous properties can not be excluded. This substance should be handled with particular care. Liver - Irregularities - Based on Human Evidence

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Persistence and degradability	Biodegradability aerobic - Exposure time 28 d Result: 70 % - Readily biodegradable. (OECD Test Guideline 301C) Remarks: The 10 day time window criterion is not fulfilled.
Toxicity to fish	Static test LC50 - Leuciscus idus (Golden orfe) - > 500 mg/l - 96 h (DIN 38412 T15)
Toxicity to daphnia and other aquatic invertebrates	Static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h (Regulation (EC) No. 440/2008, Annex, C.2)
Toxicity to algae	Static test ErC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 72 h (DIN 38412)
Products Biodegradation	The methods for determining the biological degradability are not applicable to inorganic substances.
Mobility in soil	No Information available
Results of PBT and vPvB assessment	This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Endocrine disrupting properties	The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Other adverse effects	No data available

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Disposal methods	The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging	Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
Waste treatment Method	See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

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UN number	ADR/RID: IMDG: IATA:
UN proper shipping name	ADR/RID: IMDG: IATA:
Transport hazard class(es)	ADR/RID: IMDG: IATA:
Packaging group	ADR/RID: IMDG: IATA:
Environmental hazards	ADR/RID: No IMDG: No IATA: No
Special precautions for user	Tunnel restriction code : (C/E)
Further information	Not classified as dangerous in the meaning of transport regulations.
Transport in bulk according to IMOinstruments	No data available

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Inventory status	Components are on the following inventories: Polymaleic acid: - US TSCA, Canadian DSL, EU EINECS, Australian AICS, Korean, Philippine PICCS and Chinese Xi irritant R 36/38 Irritant to eyes & skin R 41 Risk of serious damage to eyes S24/25 Avoid contact with skin and eyes S26/28 In case of contact eyes & skin, rinse with plenty water and seek medical advice Section 312/313: Not listed. Not listed under California proposition 65.
Safety, health and environmental regulations/legislation specific for the substance or mixture	This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
Safety, health and environmental regulations specific for the product in question	European Inventory of Existing Commercial Chemical Substances (EINECS) -Listed.EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory- Listed. China Catalog of Hazardous chemicals 2015 Not- Listed. New Zealand Inventory of Chemicals (NZIoC)Listed. PICCS -Listed. Vietnam National Chemical Inventory -Listed. IECSC Listed. Korea Existing Chemicals List (KECL) -Listed.
National legislation	Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : OXIDISING LIQUIDS AND SOLIDS : ENVIRONMENTAL HAZARDS
Authorisations and/or restrictions on use	REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : N,N-Dimethylacetamide REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII) : N,N-Dimethylacetamide
Other regulations	Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work.
Chemical Safety Assessment	A Chemical Safety Assessment has been carried out for this substance.

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Other Information

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages.

DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable.